The Semax / Selank (Blend) is strictly for laboratory research and is commonly employed in the following investigational areas:

Neuroprotection and Ischemia Models

Semax is heavily investigated for its neuroprotective mechanisms during the acute periods of ischemic stroke and focal ischemia. Researchers utilize this compound to observe the restoration of cognitive function in chronic brain ischemia and to track the expression of genes related to the vascular and immune systems.

Neurotransmitter & BDNF Regulation

Experimental models utilize these peptides to study their impact on brain chemistry. Semax is shown to bind specifically and increase levels of brain-derived neurotrophic factor (BDNF) in the basal forebrain, while affecting dopaminergic, serotonergic, and cholinergic neurons. Similarly, Selank is researched for its ability to regulate BDNF content in the hippocampus and prefrontal cortex, protecting against ethanol-induced memory impairment.

Stress Response and Immunomodulation

Both Semax and Selank demonstrate significant immunomodulating action in “social” and acute stress models. Investigations focus on how these peptides influence the levels of pro- and anti-inflammatory cytokines, chemokine receptor expression, and the intensity of lipid peroxidation in immunocompetent organs. Selank is also studied for its effects on morphological changes in the large intestine under chronic restraint stress.

Amyloid Aggregation

In artificial membrane models, Semax is utilized as a chemical probe to study its effects on copper-induced Abeta aggregation and amyloid formation.

Preclinical Research Summary

Published preclinical literature documents investigations of Semax and Selank across multiple experimental models for pathway characterization:

• Cognitive & Memory Assays: Studies indicate Selank protects against memory impairment by regulating BDNF, while Semax aids in cognitive function restoration in brain ischemia models.
• Stress Models: Research demonstrates that Semax and Selank alter cytokine expression and lipid peroxidation under conditions of “social” and acute stress.
• Neuro-protective Assays: Data suggest Semax affects gene expression related to the immune and vascular systems during brain focal ischemia and influences neuronal viability.

Form & Analytical Testing

This material is produced via robust chemical synthesis and supplied as a lyophilized (freeze-dried) powder.

• Lyophilization: Removes water content under vacuum to maintain compound integrity and extend shelf-life.
• Identity Verification: Each lot undergoes Mass Spectrometry (MS) to confirm molecular weight and identity.
• Purity Verification: High-Performance Liquid Chromatography (HPLC) is performed to ensure the product meets the ≥99% purity standard required for reproducible research data.

Referenced Citations

References are provided for informational purposes only and are not clinical claims.

• Sciacca, M., Naletova, I., Giuffrida, M., & Attanasio, F. (2022). Semax, a Synthetic Regulatory Peptide, Affects Copper-Induced Abeta Aggregation and Amyloid Formation in Artificial Membrane Models. ACS Chemical Neuroscience, 13, 486 – 496. https://doi.org/10.1021/acschemneuro.1c00707.
• Miasoedova, N., et al. (1999). [Investigation of mechanisms of neuroprotective effect of semax in athe cute period of ischemic stroke]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 99 5, 15-9. https://pubmed.ncbi.nlm.nih.gov/17603664/.
• Kirchev, V. (2023). Cognitive function restoration in rats with chronic brain ischemia using Semax and hopantenic acid comprehensive administration. Journal of Education, Health and Sport. https://doi.org/10.12775/jehs.2023.13.04.046.
• Eremin, K., et al. (2004). Effects of Semax on Dopaminergic and Serotoninergic Systems of the Brain. Doklady Biological Sciences, 394, 1-3. https://doi.org/10.1023/B:DOBS.0000017114.24474.40.
• Dolotov, O., et al. (2006). Semax, an analogue of adrenocorticotropin (4–10), binds specifically and increases levels of brain‐derived neurotrophic factor protein in rat basal forebrain. Journal of Neurochemistry, 97. https://doi.org/10.1111/j.1471-4159.2006.03658.x.
• Grivennikov, I., et al. (2008). Effects of behaviorally active ACTH (4-10) analogue – Semax on rat basal forebrain cholinergic neurons. Restorative neurology and neuroscience, 26 1, 35-43. https://pubmed.ncbi.nlm.nih.gov/18431004/.
• Yasenyavskaya, A., et al. (2022). The experimental study of the immunomodulating action of Semax and Selank on the model of „social” stress. European Pharmaceutical Journal, 69, 54 – 60. https://doi.org/10.2478/afpuc-2022-0004.
• Yasenyavskaya, A., et al. (2022). Influence of Semax on the Level of Pro- and Anti-Inflammatory Cytokines in Conditions of “Social” Stress. Current Drug Therapy. https://doi.org/10.2174/1574885517666220831155411.
• Glazova, N., et al. (2023). Effects of Semax in the Models of Acute Stress. https://doi.org/10.31857/s0869813923010053.
• Samotrueva, M., et al. (2019). INFLUENCE OF SEMAX ON THE INTENSITY OF LIPID PEROXIDATION IN IMMUNOCOMPETENT ORGANS IN THE CONDITIONS OF “SOCIAL” STRESS. 19, 188-191. https://doi.org/10.17816/maj191s1188-191.
• Medvedeva, E., et al. (2014). The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis. BMC Genomics, 15, 228 – 228. https://doi.org/10.1186/1471-2164-15-228.
• Vyunova, T., et al. (2018). Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity. Protein and peptide letters, 25 10, 914-923. https://doi.org/10.2174/0929866525666180925144642.
• Kolik, L., et al. (2019). Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats. Bulletin of Experimental Biology and Medicine, 167, 641 – 644. https://doi.org/10.1007/s10517-019-04588-9.
• Kolomin, T., et al. (2023). Changes in Expression of Chemokines, Cytokines and their Receptors under the Action of Selank and its Fragments. Journal of Clinical Physiology and Pathology. https://doi.org/10.59315/jiscpp.2023-2-2.16-18.
• Mukhina, A., et al. (2020). Morphological Changes in the Large Intestine of Rats Subjected to Chronic Restraint Stress and Treated with Selank. Bulletin of Experimental Biology and Medicine, 169, 281 – 285. https://doi.org/10.1007/s10517-020-04868-9.

• Stable at room temperature for up to 90 days. For long-term storage, keep at -20°C (-4°F) or colder.
• Once mixed with a solvent (e.g., bacteriostatic water), the solution must be stored at 4 °C (39°F) and utilized within 30 days. Avoid repeated freeze-thaw cycles, as this degrades the peptide structure.

RESEARCH USE ONLY

This product is intended strictly for laboratory research use only. It is not for human or veterinary use. It is not intended for diagnosis, treatment, cure, or prevention of any disease. All purchases are subject to our Terms of Service and Purity Guarantee.

No COAs available for this product.